{"id":6878,"date":"2026-04-20T14:32:14","date_gmt":"2026-04-20T05:32:14","guid":{"rendered":"https:\/\/simagebank.net\/wp\/?p=6878"},"modified":"2026-04-20T14:32:55","modified_gmt":"2026-04-20T05:32:55","slug":"%eb%8d%b0%ec%9d%b4%ed%84%b0-%eb%a6%ac%ed%8f%ac%ed%8a%b8-crispr-cas9%ec%9d%98-%ec%a0%95%eb%b0%80%ed%99%94-af3%eb%a5%bc-%eb%84%98%ec%96%b4-100th-percentile-%eb%ac%b4%ea%b2%b0%ec%84%b1-%eb%8b%ac","status":"publish","type":"post","link":"https:\/\/simagebank.net\/wp\/6878\/","title":{"rendered":"[\ub370\uc774\ud130 \ub9ac\ud3ec\ud2b8] CRISPR-Cas9\uc758 \uc815\ubc00\ud654: AF3\ub97c \ub118\uc5b4 100th Percentile \ubb34\uacb0\uc131 \ub2ec\uc131"},"content":{"rendered":"<p style=\"text-align: center;\" data-path-to-node=\"3\">\ub2e8\ubc31\uc9c8 \uad6c\uc870 \uc608\uce21 AI\uc778 AlphaFold3(AF3)\ub294 \ud601\uc2e0\uc801\uc778 \ub3c4\uad6c\uc774\uc9c0\ub9cc, \uac70\ub300 \ud575\uc0b0 \ubcf5\ud569\uccb4(Nucleoprotein) \uc2dc\ubbac\ub808\uc774\uc158\uc5d0\uc11c\ub294 \uc5ec\uc804\ud788 \ubbf8\uc138\ud55c \uae30\ud558\ud559\uc801 \uc624\ub958\ub97c \ub0a8\uae41\ub2c8\ub2e4. \ubcf8 \ub9ac\ud3ec\ud2b8\uc5d0\uc11c\ub294 \uc720\uc804\uc790 \uac00\uc704\ub85c \uc798 \uc54c\ub824\uc9c4 4UN3(Cas9-sgRNA-DNA \ubcf5\ud569\uccb4)\ub97c \ub300\uc0c1\uc73c\ub85c <b data-path-to-node=\"3\" data-index-in-node=\"158\">HanjariFold ZENITH<\/b> \uc5d4\uc9c4\uc774 \ub2ec\uc131\ud55c \ubb3c\ub9ac\uc801 \uc815\uc81c \uc131\uacfc\ub97c \ud329\ud2b8 \uc911\uc2ec\uc73c\ub85c \uc694\uc57d\ud569\ub2c8\ub2e4.<\/p>\n<h3 style=\"text-align: center;\" data-path-to-node=\"4\">1. \uc8fc\uc694 \uc9c0\ud45c \ube44\uad50: AF3 \uc6d0\ubcf8 vs HanjariFold ZENITH<\/h3>\n<p style=\"text-align: center;\" data-path-to-node=\"5\">\uac00\uc7a5 \uac1d\uad00\uc801\uc778 \uad6c\uc870 \uac80\uc99d \uc9c0\ud45c\uc778 <b data-path-to-node=\"5\" data-index-in-node=\"18\">MolProbity<\/b> \ubd84\uc11d \uacb0\uacfc, HanjariFold\ub294 \uac70\ub300 \ubcf5\ud569\uccb4\uc758 \ud55c\uacc4\ub97c \uadf9\ubcf5\ud558\uace0 \uc138\uacc4 \ucd5c\uc0c1\uc704 0% \uc218\uc900\uc758 \uc815\ubc00\ub3c4\uc5d0 \ub3c4\ub2ec\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: center;\" data-path-to-node=\"5\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1638 size-full\" src=\"https:\/\/proteinmaker.net\/wp\/wp-content\/uploads\/2026\/04\/af3_4UN3_f_02.png\" alt=\"\" width=\"735\" height=\"476\" \/><\/p>\n<p style=\"text-align: center;\" data-path-to-node=\"5\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1636 size-large\" src=\"https:\/\/proteinmaker.net\/wp\/wp-content\/uploads\/2026\/04\/af3_4UN3_01-1024x332.png\" alt=\"\" width=\"1024\" height=\"332\" \/><\/p>\n<p style=\"text-align: center;\" data-path-to-node=\"5\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1637 size-large\" src=\"https:\/\/proteinmaker.net\/wp\/wp-content\/uploads\/2026\/04\/af3_4UN3_f_01-1024x349.png\" alt=\"\" width=\"1024\" height=\"349\" \/><\/p>\n<p style=\"text-align: center;\" data-path-to-node=\"5\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1635 size-large\" src=\"https:\/\/proteinmaker.net\/wp\/wp-content\/uploads\/2026\/04\/af3_4UN3_f_surface_01-1024x531.png\" alt=\"\" width=\"1024\" height=\"531\" \/><\/p>\n<h3 style=\"text-align: center;\" data-path-to-node=\"8\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1642 size-large\" src=\"https:\/\/proteinmaker.net\/wp\/wp-content\/uploads\/2026\/04\/4UN3_pdb-1024x349.png\" alt=\"\" width=\"1024\" height=\"349\" \/><\/h3>\n<h3 style=\"text-align: center;\" data-path-to-node=\"8\">2. \ud575\uc2ec \uc815\uc81c \ud329\ud2b8 \ubd84\uc11d<\/h3>\n<h4 style=\"text-align: center;\" data-path-to-node=\"9\">\u2460 \ud575\uc0b0(DNA\/RNA) \uad6c\uc870\uc758 \uc644\uc804\ud55c \uad50\uc815<\/h4>\n<p style=\"text-align: center;\" data-path-to-node=\"10\">AF3 \uc6d0\ubcf8 \ub370\uc774\ud130\uc5d0\uc11c\ub294 \ud575\uc0b0 \ubd80\ubd84\uc5d0\uc11c 6\uac1c\uc758 <b data-path-to-node=\"10\" data-index-in-node=\"26\">Bad Bonds<\/b>\uac00 \ubc1c\uacac\ub418\uc5b4 \uc801\uc0c9 \uacbd\uace0(Red)\uac00 \ub5b4\uc2b5\ub2c8\ub2e4. HanjariFold ZENITH\ub294 \uc774\ub97c 0\uac1c(0.00%)\ub85c \uc644\ubcbd\ud558\uac8c \uad50\uc815\ud558\uc5ec, \uc720\uc804\uc790 \uac00\uc704\uc758 \ud575\uc2ec\uc778 DNA\/RNA \uacb0\ud569 \ubd80\uc704\uc758 \ubb3c\ub9ac\uc801 \uc2e0\ub8b0\uc131\uc744 \ud655\ubcf4\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<h4 style=\"text-align: center;\" data-path-to-node=\"11\">\u2461 3,487\uac1c\uc758 &#8216;\ud65c\uc131 \uc218\ubd84&#8217; \ubc30\uce58\uc640 \uc804\ud558 \ucc28\ud3d0<\/h4>\n<p style=\"text-align: center;\" data-path-to-node=\"12\">Cas9 \ubcf5\ud569\uccb4\ub294 \uac15\ud55c \uc804\ud558\ub97c \ub760\ub294 \ud575\uc0b0\uc774 \ud3ec\ud568\ub418\uc5b4 \uc788\uc5b4 \uc815\uc804\uae30\uc801 \ubd88\uc548\uc815\uc131\uc774 \ub192\uc2b5\ub2c8\ub2e4. HanjariFold\ub294 \uae30\uc874\uc5d0 \uc5c6\ub358 <b data-path-to-node=\"12\" data-index-in-node=\"69\">3,487\uac1c\uc758 \ubb3c \ubd84\uc790<\/b>\ub97c \ucd5c\uc801\uc758 \uc704\uce58\uc5d0 \ubc30\uce58(Equilibrium Hydration)\ud558\uc5ec, \ub2e8\ubc31\uc9c8\uacfc \ud575\uc0b0 \uc0ac\uc774\uc758 \uc804\ud558 \ubc18\ubc1c\uc744 \uc911\ud654\ud558\uace0 \uc218\uc18c \uacb0\ud569\ub9dd\uc744 \uc644\uc131\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<h4 style=\"text-align: center;\" data-path-to-node=\"13\">\u2462 Clashscore\uc758 \ud68d\uae30\uc801 \uac1c\uc120 (8.49 \u2192 2.19)<\/h4>\n<p style=\"text-align: center;\" data-path-to-node=\"14\">\uac70\ub300 \ubcf5\ud569\uccb4\uc784\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ucda9\ub3cc \uc9c0\uc218\ub97c 2.19\uae4c\uc9c0 \ub0ae\ucdc4\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ubd84\uc790 \uc5ed\ud559(MD) \uc2dc\ubbac\ub808\uc774\uc158\uc774\ub098 \ub3c4\ud0b9 \uacc4\uc0b0 \uc2dc \uc5d0\ub108\uc9c0 \ud3ed\ubc1c \ub9ac\uc2a4\ud06c\ub97c \uc81c\uac70\ud558\uace0, \uc6d0\uc790 \uc218\uc900\uc5d0\uc11c\uc758 \uc0c1\ud638\uc791\uc6a9 \ubd84\uc11d\uc744 \uac00\ub2a5\ud558\uac8c \ud558\ub294 <b data-path-to-node=\"14\" data-index-in-node=\"109\">&#8216;\uc2e4\ud589 \uac00\ub2a5\ud55c(Actionable)&#8217;<\/b> \uad6c\uc870\uc784\uc744 \uc785\uc99d\ud569\ub2c8\ub2e4.<\/p>\n<hr data-path-to-node=\"15\" \/>\n<h3 style=\"text-align: center;\" data-path-to-node=\"16\">3. \uc0dd\ubb3c\ud559\uc801 \ubc0f \uc0b0\uc5c5\uc801 \uc758\uc758<\/h3>\n<p style=\"text-align: center;\" data-path-to-node=\"17\">\uc774 \uc815\ub3c4 \uc218\uc900\uc758 \uc815\ubc00\ud654\ub294 \uc720\uc804\uc790 \uad50\uc815 \uae30\uc220 \uc5f0\uad6c\uc5d0 \uc788\uc5b4 \ub2e4\uc74c\uacfc \uac19\uc740 \uc2e4\uc9c8\uc801\uc778 \uac00\uce58\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n<ul style=\"text-align: center;\" data-path-to-node=\"18\">\n<li>\n<p data-path-to-node=\"18,0,0\"><b data-path-to-node=\"18,0,0\" data-index-in-node=\"0\">\uc624\ud504 \ud0c0\uac9f(Off-target) \uc608\uce21 \uc815\ubc00\ub3c4 \ud5a5\uc0c1:<\/b> \uac00\uc774\ub4dc RNA\uc640 \ud0c0\uac9f DNA\uac00 \ub9cc\ub098\ub294 \uc9c0\uc810\uc758 \uc6d0\uc790 \uc88c\ud45c\uac00 \uc815\ud655\ud574\uc9d0\uc5d0 \ub530\ub77c, \ube44\ud2b9\uc774\uc801 \uacb0\ud569 \uac00\ub2a5\uc131\uc744 \ub354\uc6b1 \uc815\uad50\ud558\uac8c \uc608\uce21\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,1,0\"><b data-path-to-node=\"18,1,0\" data-index-in-node=\"0\">\uc808\ub2e8 \ud6a8\uc728 \ucd5c\uc801\ud654:<\/b> Cas9 \ud65c\uc131 \ubd80\uc704(Active Site)\uc758 \uae30\ud558\ud559\uc801 \uc65c\uace1\uc774 \uc0ac\ub77c\uc838, \ubcc0\uc774\uccb4 \uc124\uacc4 \uc2dc \uc544\ubbf8\ub178\uc0b0 \uce58\ud658\uc5d0 \ub530\ub978 \uc5d0\ub108\uc9c0 \ubcc0\ud654\ub97c \uc815\ud655\ud788 \uacc4\uc0b0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"18,2,0\"><b data-path-to-node=\"18,2,0\" data-index-in-node=\"0\">\ub370\uc774\ud130 \ud30c\uc6b4\ub4dc\ub9ac\uc758 \ube44\uc804:<\/b> \ub2e8\ubc31\uc9c8\uc744 \ub118\uc5b4 \ud575\uc0b0 \ubcf5\ud569\uccb4\uae4c\uc9c0 <b data-path-to-node=\"18,2,0\" data-index-in-node=\"31\">MP 1.00<\/b> \uc601\uc5ed\uc73c\ub85c \ubc00\uc5b4 \ub123\ub294 \uae30\uc220\ub825\uc740, \uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc720\uc804\uc790 \uce58\ub8cc\uc81c \uc124\uacc4\uc758 \uc0c8\ub85c\uc6b4 \ud45c\uc900(Gold Standard)\uc774 \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n<\/li>\n<\/ul>\n<hr data-path-to-node=\"19\" \/>\n<h3 style=\"text-align: center;\" data-path-to-node=\"20\">\uacb0\ub860: &#8220;\ubb3c\ub9ac \ubc95\uce59\uc73c\ub85c AI\uc758 \ud55c\uacc4\ub97c \uba54\uc6b0\ub2e4&#8221;<\/h3>\n<p style=\"text-align: center;\" data-path-to-node=\"21\">HanjariFold ZENITH V34.1\uc740 Cas9\uacfc \uac19\uc740 \ucd08\uac70\ub300 \uc2dc\uc2a4\ud15c\uc5d0\uc11c\ub3c4 \ubb3c\ub9ac\uc801 \ud544\uc5f0\uc131\uc744 \ucc3e\uc544\ub0c8\uc2b5\ub2c8\ub2e4. 3,487\uac1c\uc758 \ubb3c \ubd84\uc790\uc640 \ud568\uaed8 \uc644\uc131\ub41c \uc774 \uad6c\uc870\ub294 \uc774\uc81c \ub2e8\uc21c\ud55c \uc608\uce21 \ubaa8\ub378\uc774 \uc544\ub2cc, &#8216;\uac80\uc99d\ub41c \ubb3c\ub9ac\uc801 \uc2e4\uccb4&#8217;\ub85c\uc11c \uc5f0\uad6c \ud604\uc7a5\uc5d0 \ud22c\uc785\ub420 \uc900\ube44\ub97c \ub9c8\ucce4\uc2b5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: center;\" data-path-to-node=\"22\">\ubcf8 \uad6c\uc870\uc758 PDB \ud30c\uc77c \ubc0f \uc0c1\uc138 \uac80\uc99d \ub9ac\ud3ec\ud2b8\ub294 \uae30\uc220 \ube14\ub85c\uadf8\ub97c \ud1b5\ud574 \uacf5\uc720\ub429\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: center;\" data-path-to-node=\"22\"><a href=\"https:\/\/proteinmaker.net\/wp\/wp-content\/uploads\/2026\/04\/AF3_4UN3_01.zip\">AF3_4UN3_01<\/a><\/p>\n<p data-path-to-node=\"22\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1644 size-large aligncenter\" src=\"https:\/\/proteinmaker.net\/wp\/wp-content\/uploads\/2026\/04\/af3_4UN3_f_f_01-1024x354.png\" alt=\"\" width=\"1024\" height=\"354\" \/><\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"oTmgK8BJqg\"><p><a href=\"https:\/\/proteinmaker.net\/wp\/%eb%8d%b0%ec%9d%b4%ed%84%b0-%eb%a6%ac%ed%8f%ac%ed%8a%b8-crispr-cas9%ec%9d%98-%ec%a0%95%eb%b0%80%ed%99%94-af3%eb%a5%bc-%eb%84%98%ec%96%b4-100th-percentile-%eb%ac%b4%ea%b2%b0%ec%84%b1-%eb%8b%ac\/\">[\ub370\uc774\ud130 \ub9ac\ud3ec\ud2b8] CRISPR-Cas9\uc758 \uc815\ubc00\ud654: AF3\ub97c \ub118\uc5b4 100th Percentile \ubb34\uacb0\uc131 \ub2ec\uc131<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;[\ub370\uc774\ud130 \ub9ac\ud3ec\ud2b8] CRISPR-Cas9\uc758 \uc815\ubc00\ud654: AF3\ub97c \ub118\uc5b4 100th Percentile \ubb34\uacb0\uc131 \ub2ec\uc131&#8221; &#8212; ProteinMaker\" src=\"https:\/\/proteinmaker.net\/wp\/%eb%8d%b0%ec%9d%b4%ed%84%b0-%eb%a6%ac%ed%8f%ac%ed%8a%b8-crispr-cas9%ec%9d%98-%ec%a0%95%eb%b0%80%ed%99%94-af3%eb%a5%bc-%eb%84%98%ec%96%b4-100th-percentile-%eb%ac%b4%ea%b2%b0%ec%84%b1-%eb%8b%ac\/embed\/#?secret=cay1eIWKlg#?secret=oTmgK8BJqg\" data-secret=\"oTmgK8BJqg\" width=\"580\" height=\"327\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ub2e8\ubc31\uc9c8 \uad6c\uc870 \uc608\uce21 AI\uc778 AlphaFold3(AF3)\ub294 \ud601\uc2e0\uc801\uc778 \ub3c4\uad6c\uc774\uc9c0\ub9cc, \uac70\ub300 \ud575\uc0b0 \ubcf5\ud569\uccb4(Nucleoprotein) \uc2dc\ubbac\ub808\uc774\uc158\uc5d0\uc11c\ub294 \uc5ec\uc804\ud788 \ubbf8\uc138\ud55c \uae30\ud558\ud559\uc801 \uc624\ub958\ub97c \ub0a8\uae41\ub2c8\ub2e4. \ubcf8 \ub9ac\ud3ec\ud2b8\uc5d0\uc11c\ub294 \uc720\uc804\uc790 \uac00\uc704\ub85c \uc798 \uc54c\ub824\uc9c4 4UN3(Cas9-sgRNA-DNA \ubcf5\ud569\uccb4)\ub97c \ub300\uc0c1\uc73c\ub85c HanjariFold ZENITH \uc5d4\uc9c4\uc774 \ub2ec\uc131\ud55c \ubb3c\ub9ac\uc801 \uc815\uc81c \uc131\uacfc\ub97c \ud329\ud2b8 \uc911\uc2ec\uc73c\ub85c \uc694\uc57d\ud569\ub2c8\ub2e4. 1. \uc8fc\uc694 \uc9c0\ud45c \ube44\uad50: AF3 \uc6d0\ubcf8 vs HanjariFold ZENITH \uac00\uc7a5 \uac1d\uad00\uc801\uc778 \uad6c\uc870 \uac80\uc99d \uc9c0\ud45c\uc778 MolProbity \ubd84\uc11d \uacb0\uacfc, HanjariFold\ub294 \uac70\ub300 \ubcf5\ud569\uccb4\uc758 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"templates\/template-full-width.php","format":"standard","meta":{"footnotes":""},"categories":[1138,201,1139,44,635],"tags":[3874,4002,3991,4003,3994,203,3995,3992,206,4004,1023],"class_list":["post-6878","post","type-post","status-publish","format-standard","hentry","category-1138","category-201","category-1139","category-44","category-635","tag-af3","tag-ai","tag-alphafold3","tag-cas9","tag-clashscore","tag-dna","tag-hanjarifold","tag-molprobity","tag-rna","tag-4004","tag-1023"],"aioseo_notices":[],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/posts\/6878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/comments?post=6878"}],"version-history":[{"count":1,"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/posts\/6878\/revisions"}],"predecessor-version":[{"id":6879,"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/posts\/6878\/revisions\/6879"}],"wp:attachment":[{"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/media?parent=6878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/categories?post=6878"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/simagebank.net\/wp\/wp-json\/wp\/v2\/tags?post=6878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}