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제목Protein Function2023-09-06 20:04
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Protein Function

https://www.ncbi.nlm.nih.gov/books/NBK26911/


We have seen that each type of protein consists of a precise sequence of amino acids that allows it to fold up into a particular three-dimensional shape, or conformation. But proteins are not rigid lumps of material. They can have precisely engineered moving parts whose mechanical actions are coupled to chemical events. It is this coupling of chemistry and movement that gives proteins the extraordinary capabilities that underlie the dynamic processes in living cells.


In this section, we explain how proteins bind to other selected molecules and how their activity depends on such binding. We show that the ability to bind to other molecules enables proteins to act as catalysts, signal receptors, switches, motors, or tiny pumps. The examples we discuss in this chapter by no means exhaust the vast functional repertoire of proteins. However, the specialized functions of many of the proteins you will encounter elsewhere in this book are based on similar principles.

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Antibody, Microbiome, Mitochondria, Nanobodies, Protein engineering, Identification of Bacteria, Systems Biology, Structural biology,


Nanobodies

A comprehensive comparison between camelid nanobodies and single chain variable fragments

https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-021-00332-6

The Therapeutic Potential of Nanobodies

https://link.springer.com/article/10.1007/s40259-019-00392-z

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

https://www.nature.com/articles/s41467-021-25480-z

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

https://www.science.org/doi/10.1126/science.abe3255

Antibody

Antibodies to combat viral infections: development strategies and progress

https://www.nature.com/articles/s41573-022-00495-3

Microbiome

Gut microbiota in human metabolic health and disease

https://www.nature.com/articles/s41579-020-0433-9

Current understanding of the human microbiome

https://www.nature.com/articles/nm.4517

A framework for microbiome science in public health

https://www.nature.com/articles/s41591-021-01258-0

Mitochondria

Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes

https://www.nature.com/articles/s41586-022-05288-7

Protein engineering

Advances in protein structure prediction and design

https://www.nature.com/articles/s41580-019-0163-x

https://www.nature.com/subjects/protein-engineering

Identification of Bacteria

16S rRNA 유전자 염기서열분석을 통한 임상 미생물학에서의 세균동정

https://kosen.kr/info/kosen/273696

16S rRNA 및 Internal Transcribed Spacer 염기서열 분석법을 이용한 세균 및 진균 동정

https://synapse.koreamed.org/upload/synapsedata/pdfdata/0105kjcm/kjcm-13-34.pdf