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제목Fast and accurate protein structure search with Foldseek2023-09-06 21:00
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Fast and accurate protein structure search with Foldseek

https://www.nature.com/articles/s41587-023-01773-0


Abstract

As structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a structural alphabet. Foldseek decreases computation times by four to five orders of magnitude with 86%, 88% and 133% of the sensitivities of Dali, TM-align and CE, respectively.

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