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제목Current understanding of the human microbiome2023-09-15 21:46
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Current understanding of the human microbiome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043356/


Abstract

Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes, and mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this Review, we focus on studies in humans to describe these challenges, and propose strategies that leverage existing knowledge to move rapidly from correlation to causation, and ultimately to translation.


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Antibody, Microbiome, Mitochondria, Nanobodies, Protein engineering, Identification of Bacteria, Systems Biology, Structural biology,


Nanobodies

A comprehensive comparison between camelid nanobodies and single chain variable fragments

https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-021-00332-6

The Therapeutic Potential of Nanobodies

https://link.springer.com/article/10.1007/s40259-019-00392-z

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

https://www.nature.com/articles/s41467-021-25480-z

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

https://www.science.org/doi/10.1126/science.abe3255

Antibody

Antibodies to combat viral infections: development strategies and progress

https://www.nature.com/articles/s41573-022-00495-3

Microbiome

Gut microbiota in human metabolic health and disease

https://www.nature.com/articles/s41579-020-0433-9

Current understanding of the human microbiome

https://www.nature.com/articles/nm.4517

A framework for microbiome science in public health

https://www.nature.com/articles/s41591-021-01258-0

Mitochondria

Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes

https://www.nature.com/articles/s41586-022-05288-7

Protein engineering

Advances in protein structure prediction and design

https://www.nature.com/articles/s41580-019-0163-x

https://www.nature.com/subjects/protein-engineering

Identification of Bacteria

16S rRNA 유전자 염기서열분석을 통한 임상 미생물학에서의 세균동정

https://kosen.kr/info/kosen/273696

16S rRNA 및 Internal Transcribed Spacer 염기서열 분석법을 이용한 세균 및 진균 동정

https://synapse.koreamed.org/upload/synapsedata/pdfdata/0105kjcm/kjcm-13-34.pdf