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제목Protein engineering for improving and diversifying natural products biosynthesis2023-09-16 16:03
작성자 Level 8

Protein engineering for improving and diversifying natural products biosynthesis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274900/


Abstract

Proteins found in nature have traditionally been the most frequently used biocatalysts to produce numerous natural products ranging from commodity chemicals to pharmaceuticals. Protein engineering has emerged as a powerful biotechnological toolbox in the development of metabolic engineering, particularly for the biosynthesis of natural products. Recently, protein engineering has become a favored method to improve enzymatic activities, strengthen enzyme stabilities, and expand product spectra in natural products biosynthesis. This review summarizes recent advances and typical strategies in protein engineering, while highlighting the paramount role of protein engineering in improving and diversifying biosynthesis of natural products. Future prospects and research directions are also discussed.


Keywords: protein engineering, natural products, engineered biosynthesis

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